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KMID : 0361120190330040112
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Korean Journal of Transplantation
2019 Volume.33 No. 4 p.112 ~ p.117
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Deceased donor liver transplantation under the Korean model for end-stage liver disease score-based liver allocation system: 2-year allocation results at a high-volume transplantation center
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Ha Hea-Seon
Hong Jung-Ja
Kim In-Ok
Lee Sae-Rom
Lee Ah-Young
Ha Tae-Yong
Song Gi-Won
Jung Dong-Hwan
Park Gil-Chun
Ahn Chul-Soo
Moon Deok-Bog
Kim Ki-Hun
Lee Sung-Gyu
Hwang Shin
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Abstract
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Background: The Korean model for end-stage liver disease (MELD) score-based liver allocation system was started in June 2016 in Korea.
Methods: This study analyzed the detailed allocation results of deceased donor liver transplantation (DDLT) during the first 2 years after the MELD score-based liver allocation system implementation at a high-volume liver transplantation (LT) center in Korea.
Results: This study included 174 patients with age above 12 years. The patient ABO blood groups were A (n=65, 37.4%), B (n=51, 29.3%), O (n=28, 16.1%), and AB (n=30, 17.2%). The LT types were primary LT in 141 patients (81.0%) and retransplantation in 33 (19.0%). The Korean Network for Organ Sharing status categories at LT were as follows: status 1 (n=11, 6.3%), status 2 (n=82, 47.1%), status 3 (n=63, 36.2%), and status 4 (n=18, 10.3%). The mean MELD score at LT and waiting period were 36.6±4.6 and 62.1±98.2 days in blood group A; 37.6±3.6 and 25.7±38.1 days in blood group B; 38.8±2.7 and 26.0±30.5 days in blood group O; and 34.8±5.5 and 68.4±110.5 days in blood group AB (P<0.001 and P=0.012), respectively. Patients with blood group O and AB had the highest and lowest mean MELD scores at LT allocation, respectively.
Conclusions: Serious deceased organ donor shortage resulted in very high MELD score cutoffs for DDLT allocation. Additionally, a significant inequality was observed in the possibility for DDLT according to blood group compatibility. Nationwide follow-up studies are necessary to precisely determine the allocation status of DDLT.
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KEYWORD
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Liver transplantation, Model for end-stage liver disease score, Waiting list, ABO blood group, Deceased donor
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